BioQuateBioQuateInnovative Disposable Products for the Biotech Industry

BioQuate Disposable Aseptic Connector. . .

. . . is your next evolutionary step in single-use connectors providing aseptic/sterile connection between tubing and large bore for high fluid throughput.

Disposable Aseptic ConnectorThe BioQuate innovative Disposable Aseptic Connector (DAC) offers a safe, simple, and economical option for your biopharmaceutical production settings.

Benefits to you:

  • Connections made quickly and easily
  • Rapid setup and cleanup
  • Safe, secure, single-use connection
  • Genderless design reduces inventory, increases flexibility
  • Simple validation
  • Requires no heavy or bulky operating equipment
  • No capital equipment to purchase
  • No power, calibration, or service required
  • Allows for on-site manifold fabrication

Features:

  • Large bore (ID) for high throughput
  • Standard hose barb sizes
  • Complete product containment
  • Gamma compatible
  • All fluid path components USP Class VI
  • Useable on thermoset (silicone) and thermoplastic tubing materials
  • Built around ISO Standard 2852 for Sanitary Couplings
  • Fits sanitary clamps for permanent, high-pressure applications
  • Easy-to-use Tip n' Latch alignment system

The BioQuate Disposable Aseptic Connector (DAC) and its components are manufactured in compliance with the current Good Manufacturing Practices of the FDA and ISO 9000-2000.

Verification of the DAC connections was conducted by Northview Laboratories, Inc.

Operation:

Step 1 1. Remove the shrink band, cap and release paper from the face of each DAC connector.

The Disposable Aseptic Connector (DAC) is supplied to OEM customers fully assembled, non-sterile, and packaged in bulk quantities. In a typical application, the DAC is assembled to the tubing by the bag manufacturer through the use of the hose barb, and the complete unit is sterilized by Gamma radiation, prior to sale. The sterility of the fluid path is maintained by the removable (rolling) membrane, which is folded back upon itself and adhesively held in place over the sterile sealing surface (gasket) by a release paper and a dust cover.

In the operation sequence (figure 1), the shrink band, dust cap, and the release paper are removed from the face of the connector, revealing a fully adhesive surface. The connector (figure 2) is then held facing an opposing connector with hook and slots of each unit on top. Each unit is then tilted to approximately 60 degrees (figure 3), the hook and slot of each unit are joined, and the units rotated down into position until the perimeter latches are engaged (figure 4). This technique forces proper alignment of the two units prior to engagement of the perimeter latches. The adhesive faces of each DAC are now in contact, and the gaskets are pressured toward each other. The inner surface and fluid path are now sealed against any outside, environmental conditions. The rolling membranes, of both connectors become one unit as a result of the alignment and the contact of their adhesive surfaces. By bringing the tabs together and pulling down on the tabs, the rolling membranes are removed (figure 5). The removal of the membranes exposes the inner sterile surface of one connector to the inner sterile surface of the other, all within the sealed micro environment created in figure 4. The membrane removal also exposes the sterile silicone gasket surfaces and the sterile fluid pathways. The membranes, once removed, can be discarded (figure 5). The application of a standard sanitary clamp (figure 6) completes the union and produces a permanent, high-pressure connection.

For complete instructions and information on DAC Operation, request "Instructions for Use" and "Theory of Operation" from the Contact Page.

Step 2 2. Align each DAC, face to face, with the hook and slot of each DAC on top.
Step 3 3. Tilt the hook and slot of each DAC to engage the hook of one with the slot of the other. Rotate the units downward and engage perimeter latches.
Step 4 4. Bring the tabs together and remove the rolling membranes by pulling down the tabs.
Step 5 5. Remove the membrane completely and discard.
Step 6 6. Apply standard sanitary clamp to DAC assembly for permanent connection.

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