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The sterile components noted below constitute the building blocks
of the BioQuate Disposable Aseptic Connection System. From these
sterile components, biotech customers can fabricate, "on site,"
custom tubing manifold sets for a broad range of sterile fluid transfer
applications. Standardizing on these components reduces inventory,
improves response time, and maximizes production flexibility through
an unlimited number of component combinations. Regardless of the
tubing size or material, connection between all BioQuate DAC components
is assured. This feature encourages standardization of tubing size,
yet has none of the limitations in flexibility traditionally associated
with "standard" inventory.
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3-way DAC Assembly: various tubing lengths,
joined via a "T" and each end terminated with a DAC |
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DAC/SIP Adapter Assembly: a DAC termination
at one end of a silicone tube w/ clamp and a
Steam-In-Place Adapter at the other end |
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Cell Culture Bag (20-200 liters) with a DAC "Y"
Assembly on the fill side of the bag: Through the
use of a dual-entry DAC line, subsequent bags
can be filled on a continuous basis by cascading
the fill line of one bag onto the fill line of the next bag.
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This diagram illustrates the BioQuate Disposable Aseptic Connector
as part of specific sterile assemblies of tubing and bags permitting
the fabrication of sterile "custom" manifolds, customized
on-site, as needed, at the point of use. (Note that while sanitary
clamps are required they are not shown in this diagram to allow
for visualization of the DAC connections.) The sterile assemblies,
which form the building blocks of the DAC based manifold system,
are available from your cell culture bag manufacturer or manifold
fabricator. In this example, all the connections are made using
DACs. The DAC/Steam-In-Place Adapter allows for the connection to
a stainless steel reactor via a sanitary fitting specifically designed
for S.I.P. applications and fitted with a DAC for connection purposes
after the S.I.P process. The cell culture bags were fabricated with
a DAC "Y" configuration on the inlet side to allow for
a "cascading" fill operation from one bag to the next.
This example makes maximum use of the DAC technology. Through the
use of sterile components the need for a sterile manifold of preassembled
bags is reduced or eliminated. The same preassembly options that
are available with the traditional manifold bag approach are also
available using the DAC system. This allows for the appropriate
matching of convenience of the DAC technology with the customer
requirements for economy and production flexibility.

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