Applications for OEM Customers

The sterile components noted below constitute the building blocks of the BioQuate Disposable Aseptic Connection System. From these sterile components, biotech customers can fabricate, "on site," custom tubing manifold sets for a broad range of sterile fluid transfer applications. Standardizing on these components reduces inventory, improves response time, and maximizes production flexibility through an unlimited number of component combinations. Regardless of the tubing size or material, connection between all BioQuate DAC components is assured. This feature encourages standardization of tubing size, yet has none of the limitations in flexibility traditionally associated with "standard" inventory.

	3-way DAC Assembly: various tubing lengths, joined via a "T" and each end terminated with a DAC
	DAC/SIP Adapter Assembly: a DAC termination at one end of a silicone tube w/ clamp and a Steam-In-Place Adapter at the other end
	Cell Culture Bag (20-200 liters) with a DAC "Y" Assembly on the fill side of the bag: Through the use of a dual-entry DAC line, subsequent bags can be filled on a continuous basis by cascading the fill line of one bag onto the fill line of the next bag.

Applications for Biotech Customers

This diagram illustrates the BioQuate Disposable Aseptic Connector as part of specific sterile assemblies of tubing and bags permitting the fabrication of sterile "custom" manifolds, customized on-site, as needed, at the point of use. (Note that while sanitary clamps are required they are not shown in this diagram to allow for visualization of the DAC connections.) The sterile assemblies, which form the building blocks of the DAC based manifold system, are available from your cell culture bag manufacturer or manifold fabricator. In this example, all the connections are made using DACs. The DAC/Steam-In-Place Adapter allows for the connection to a stainless steel reactor via a sanitary fitting specifically designed for S.I.P. applications and fitted with a DAC for connection purposes after the S.I.P process. The cell culture bags were fabricated with a DAC "Y" configuration on the inlet side to allow for a "cascading" fill operation from one bag to the next. This example makes maximum use of the DAC technology. Through the use of sterile components the need for a sterile manifold of preassembled bags is reduced or eliminated. The same preassembly options that are available with the traditional manifold bag approach are also available using the DAC system. This allows for the appropriate matching of convenience of the DAC technology with the customer requirements for economy and production flexibility.

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